Healthcare professionals

What is BioDay?

BioDay is a prospective multicentre registry following patients being treated with new systemic therapies. The efficacy, safety and patient satisfaction of these new systemic agents will be investigated within the registry.

The BioDay registry is coordinated by the National Expert Centre for Constitutional Eczema, University Medical Centre Utrecht (UMCU) and the Department of Dermatology, University Medical Centre Groningen (UMCG). Several other academic and non-academic centers within the Netherlands are also affiliated with the BioDay registry.

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Data collection

Participation in the BioDay registry is open to dermatology departments in academic and non-academic hospitals with experience in difficult-to-treat atopic dermatitis (as defined by the Dutch Quality Criteria for Eczema Care).

If you are a centre interested in being part of the BioDay registry, please contact us. If you wish to participate in the BioDay registry, an initiation visit will be arranged by the research team at the UMCU or the UMCG. During this initiation visit, the study protocol to be followed, the performance of clinical assessments and the administration of various patient questionnaires will be explained. Standard texts for the EPD will be shared. This will ensure appropriate data collection. The data will be collected for a minimum of 5 years.

The BioDay medication

Biologicals
Dupilumab - since October 2017

Tralokinumab - since November 2021

Lebrikizumab - since December 2024

JAK inhibitors
Baricitinib - as of January 2021

Upadacitinib - as of October 2021

Abrocitinib - since March 2022

Sub-studies and areas of interest

In addition to primary outcome measures, such as efficacy and safety of the new systemic agents, additional research is being conducted on the impact of these drugs on:

  • Comorbidities such as asthma, food allergies and hand eczema
  • Allergic conjunctivitis and conjunctivitis during treatment
  • Microbiome development
  • Biomarkers through collection of Biobank material

Consent, sponsorship, privacy

The BioDay study protocol has been approved by the Medical Ethics Committee of the University Medical Center Utrecht and follows Good Clinical Practice guidelines.
The BioDay registry is also registered with ClinicalTrials.gov.

All participants will be informed in writing and verbally about the implications of their participation in the BioDay registry. If the patient decides to take part, he/she will have to sign an informed consent form. Data collection for the registry will be in accordance with all applicable confidentiality requirements and data protection and privacy legislation. In each participating hospital, consent will be obtained from the local medical ethics review committee and/or board of directors in accordance with local policy.

The BioDay Registry is financially supported by Sanofi/Regeneron, Abbvie, Lilly and LEO Pharma. They do not have access to the personal data of the trial participants, nor do they have any influence on the processing and publication of the trial data.

Scientific publications

Scientific publications resulting from data from the BioDay registry appear with some regularity.
Below is an overview of publications to date.

April 2026
Dupilumab versus tralokinumab in atopic dermatitis: A propensity score-adjusted comparison from BioDay

Van der Gang, et al.

 

August 2025
Upadacitinib in daily practice for refractory atopic dermatitis in adolescents: a case series of the BioDay registry

Vroman, et al. 

PubMed

August 2025
Topical Steroid Withdrawal: Perspectives of Dutch Healthcare Professionals

Vroman, et al. 

PubMed

May 2025
Treatment goals and preferences of pediatric atopic dermatitis patients, young adults, and caregivers

Van der Rijst, et al. 

PubMed

May 2025
Complementary Analysis of Local and Systemic Effects of Dupilumab in Paediatric AD Using Tape Strips and Serum

van der Rijst et al.

PubMed

March 2025
Infection risk in atopic dermatitis patients treated with biologics and JAK inhibitors: BioDay results

Van der Gang, et al. 

PubMed

March 2025
Dupilumab-Associated Ocular Surface Disease in Paediatric Atopic Dermatitis Patients: Results From the BioDay Registry

Van der Rijst, et al. 

PubMed

February 2025
Ocular surface disease in pediatric patients with moderate-to-severe atopic dermatitis

van der Rijst & Velduis, et al. 

Pubmed

January 2025
Increased Levels of Inflammatory Proteins, Including TARC/CCL17, in Skin of AD Patients During JAK Inhibitor Treatment

Boesjes, et al.

PubMed

December 2024
Tralokinumab Treatment in Adult Atopic Dermatitis Patients: 28-Week Evaluation of Clinical Effectiveness, Safety, Serum Proteins and Total IgE Levels

Dekker, et al. 

Pubmed

October 2024
Type 2 Immune-Dominant Endotype Is Not Associated With Increased Responsiveness to Dupilumab Treatment in Adult Atopic Dermatitis Patients

Dekker, et al. 

Pubmed

October 2024
Drug Survival of Dupilumab, Methotrexate, and Cyclosporine A in Children With Atopic Dermatitis

van der Rijst, et al. 

Pubmed

July 2024
Dupilumab induces a significant decrease of food specific immunoglobulin E levels in pediatric atopic dermatitis patients

van der Rijst, et al. 

Pubmed

June 2024
Effect of dupilumab on asthma and aeroallergen sensitization in pediatric atopic dermatitis patients: Results of the BioDay registry

van der Rijst, et al. 

Pubmed

February 2024
Real-world Experience of Abrocitinib Treatment in Patients with Atopic Dermatitis and Hand Eczema: Up to 28-week Results from the BioDay Registry

Kamphuis, et al. 

Pubmed

December 2023
Differential dynamics of TARC during JAK-inhibitor therapy compared to biological therapies targeting type 2 inflammation

Boesjes, et al. 

Pubmed

October 2023
Dupilumab-Associated Lymphoid Reactions in Patients With Atopic Dermatitis

Boesjes, et al. 

Pubmed

September 2023
Biologicals for pediatric patients with atopic dermatitis: practical challenges and knowledge gaps

van der Rijst, et al. 

Pubmed

September 2023
IgE levels in patients with atopic dermatitis steadily decrease during treatment with dupilumab regardless of dose interval

Dekkers, et al. 

Pubmed

May 2023
Successful tapering of dupilumab in atopic dermatitis patients with low disease activity: a large pragmatic daily practice study from the BioDay registry

Spekhorst, et al. 

Pubmed

March 2023
Biological Tipping Point in Patients with Atopic Dermatitis Treated with Different Dosing Intervals of Dupilumab

Dekkers, et al.

Pubmed

March 2023
Dupilumab-associated ocular surface disease in atopic dermatitis patients: clinical characteristics, ophthalmic treatment response, and conjunctival goblet cell analysis

Achten, et al. 

Pubmed

March 2023
Switching from dupilumab to tralokinumab in atopic dermatitis patients with ocular surface disease: Preliminary case series

Achten, et al. 

Pubmed

March 2023
Economic and Humanistic Burden in Paediatric Patients with Atopic Dermatitis

Achten, et al. 

Pubmed

February 2023
Muscle and joint pain during dupilumab treatment for atopic dermatitis: Lack of association with antinuclear antibodies

Boesjes, et al. 

Pubmed

February 2023
Effectiveness of Upadacitinib in Patients with Atopic Dermatitis including those with Inadequate Response to Dupilumab and/or Baricitinib: Results from the BioDay Registry.

Boesjes, et al. 

Pubmed

January 2023
High dupilumab levels in tear fluid of atopic dermatitis patients with moderate-to-severe ocular surface disease

Achten, et al. 

Pubmed

January 2023
Experiences from daily practice of upadacitinib treatment on atopic dermatitis with a focus on hand eczema: Results from the BioDay registry

Kamphuis, et al. 

Pubmed

January 2023
The positive effect of dupilumab on comorbid asthma in patients with atopic dermatitis

Spekhorst, et al. 

Pubmed

December 2022
Biomarkers in tear fluid of dupilumab-treated moderate-to-severe atopic dermatitis patients

Achten, et al. 

Pubmed

December 2022
Dupilumab in daily practice for the treatment of pediatric atopic dermatitis: 28-week clinical and biomarker results from the BioDay registry

Kamphuis, et al. 

Pubmed

November 2022
Daily Practice Experience of Baricitinib Treatment for Patients with Difficult-to-Treat Atopic Dermatitis: Results from the BioDay Registry.

Boesjes, et al.

Pubmed

November 2022
Dupilumab has a profound effect on specific-IgE levels of several food allergens in atopic dermatitis patients

Spekhorst, et al.

Pubmed

November 2022
Association of Serum Dupilumab Levels at 16 Weeks With Treatment Response and Adverse Effects in Patients With Atopic Dermatitis: A Prospective Clinical Cohort Study From the BioDay Registry

Spekhorst, et al.

Pubmed

September 2022
Dupilumab Drug Survival and Associated Predictors in Patients With Moderate to Severe Atopic Dermatitis: Long-term Results From the Daily Practice BioDay Registry.

Spekhorst, et al. 

Pubmed

July 2022
Patient-centered dupilumab dosing regimen leads to successful dose reduction in persistently controlled atopic dermatitis

Spekhorst, et al.

Pubmed

March 2022
Ocular surface disease is common in moderate-to-severe atopic dermatitis patients

Achten, et al.

Pubmed

March 2022
Identification of Risk Factors for Dupilumab-associated Ocular Surface Disease in Patients with Atopic Dermatitis.

Achten, et al.

Pubmed

August 2021
Rapid and Sustained Effect of Dupilumab on Work Productivity in Patients with Difficult-to-treat Atopic Dermatitis: Results from the Dutch BioDay Registry.

Ariëns, et al.

Pubmed

June 2021
Eczema control and treatment satisfaction in atopic dermatitis patients treated with dupilumab - a cross-sectional study from the BioDay registry.

Oosterhaven, et al.

Pubmed

February 2021
Early and long-term effects of dupilumab treatment on circulating T-cell functions in moderate-to-severe atopic dermatitis patients.

Bakker, et al.

Pubmed

December 2020
EASI p-EASI: Predicting disease severity in atopic dermatitis patients treated with dupilumab using a combination of serum biomarkers.

Bakker, et al.

Pubmed

October 2020
Long-term follow-up and treatment outcomes of conjunctivitis during dupilumab treatment in patients with moderate-to-severe atopic dermatitis.

Achten, et al.

Pubmed

September 2020
Dupilumab shows long-term effectiveness in a large cohort of difficult-to-treat atopic dermatitis patients in daily practice: 52-week results from the Dutch BioDay registry.

Ariëns, et al.

Pubmed

September 2020
Two-year Drug Survival of Dupilumab in a Large Cohort of Difficult-To-Treat Adult Atopic Dermatitis Patients Compared to Cyclosporine A and Methotrexate: Results From the BioDay Registry

Spekhorst, et al.

Pubmed

January 2020
Dupilumab is very effective in a large cohort of difficult-to-treat adult atopic dermatitis patients: First clinical and biomarker results from the BioDay registry.

Ariëns, et al.

Pubmed

October 2019
Dupilumab facial redness: Positive effect of itraconazole.

De Beer, et al.

Pubmed

August 2019
Effect of dupilumab on hand eczema in patients with atopic dermatitis: An observational study.

Oosterhaven, et al.

Pubmed

May 2019
Goblet cell scarcity and conjunctival inflammation during treatment with dupilumab in patients with atopic dermatitis.

Bakker, et al.

Pubmed